Risk Assessment Report – 13 November 2020

• Worldwide, there have been over 53 million cases and more than 1.29 million deaths attributed to COVID-19.

• The Gamaleya National Center of Epidemiology and Microbiology in Moscow and the Russian Direct Investment Fund

released interim Phase 3 trial results of its vaccine candidate named Sputnik V on November 11, claiming that it is 92% effective

in protecting people from COVID-19 disease manifestation without prior infection to SARS-CoV-2. The analysis was conducted

after 20 participants were infected with COVID-19 in a continuing large-scale clinical trial of 40,000 volunteers. The number of

participants is significantly lower than the 94 infections in the interim analysis results released by Pfizer and BioNTech earlier this

week. According to experts, the low number of cases reported in the Sputnik V trial indicates there is less certainty that the

vaccine’s true efficacy is above 90%, compared with the Pfizer and BioNTech analysis. More data and further follow-up is

needed before a definite conclusion on effectiveness can be made. Meanwhile, Brazil’s health regulator responded today

to the suspension of Sinovac’s Phase 3 trial in Brazil on November 9, stating that the clinical trials restarted on November 11.

According to officials, the serious adverse event registered as the death of a study volunteer in Sao Paulo was discovered as

a suicidal incident with no relation to the vaccine candidate.

• The Singapore Prime Minister said on Thursday (November 12) during ASEAN Summit (hosted by Vietnam) that Singapore will

contribute USD100,000 to the COVID-19 ASEAN Response Fund as the region continues to work together to combat the

pandemic. ASEAN leaders are also expected to sign the Regional Comprehensive Economic Partnership (RCEP) on Sunday

in what could become the world's biggest trade agreement. According to the Prime Minister, the RCEP affirms ASEAN’s

collective commitment to economic integration and to an inclusive, open and rules-based multilateral trading system. The

trade pact includes the 10-member ASEAN bloc, along with China, Japan, South Korea, Australia, New Zealand and until last

year, India, which pulled out of the deal. In addition, Sabah Local Government and Housing Minister said that several standard

operating procedures for the Sabah CMCO have been loosened in order to balance the impact of the pandemic and to

help Sabah residents lead more normal lives. The government has taken into account several factors in relaxing some

restrictions, such as allowing dine-in services at restaurants, with owners required to adhere to safety measures. Wedding

ceremonies in Sabah will also be permitted during the CMCO, but solemnizations can only be held at the state’s religious

affairs’ office. Malaysia reported 919 new COVID-19 cases on Thursday (November 12), bringing the country's total cases to

43,791.

• Malaysia’s Health Director-General said on November 12 that COVID-19 cases in Sabah were stabilizing compared to last

week and that the situation has been “brought under control”. Majority of states in Malaysia, including Sabah, are currently

under a conditional movement control order (CMCO), as the authorities attempt to tackle the resurgence of COVID-19. The

restrictions under the CMCO, which runs until December 6, include a ban on inter-state travel and the closure of schools.

• Cambodia on Wednesday (November 11) banned all state-organized events in the capital and a neighboring province for

two weeks to prevent the spread of COVID-19 after a number of people connected to a Hungarian official's visit tested